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Voici la liste de mes publications scientifiques:

Rayonnement scientifique PUBLICATIONS SCIENTIFIQUES de ROCK BRETON:

  • Faucher, F., Cantin, L., Luu-The, V., Labrie, F., and Breton, R. (2008) Crystal structures of human 5β-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry 47: 13537-13546
  • Faucher, F., Cantin, L., Luu-The, V., Labrie, F., and Breton, R. Crystal structure of human 5β-reductase (AKR1D1) defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry 47: 8261-8270
  • Méthot, M., Demers, É., Bussières, S., Desbat, B., Breton, R., and Salesse, C. (2008) Phospholipid monolayer hydrolysis by cytosolic phospholipase A2 gamma and lecithin retinolacyl transferase. Colloids and Surfaces A 321: 147-150
  • Bussières, S., Desbat, B., Breton, R., and Salesse, C. (2008) Binding of Lecithin retinol acyltransferase to phospholipid monolayers and evidence for its hydrolytic action. Biochim. Biophys. Acta 1778:1324-1334
  • Cantin, L., Faucher, F., Couture, J.-F., Pereira de Jésus-Tran, K., Legrand, P., Ciobanu, L. C., Fréchette, Y., Labrecque, R., Singh, S. M., Labrie, F., and Breton, R. (2007) Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally-designed steroidal ligand bearing a bulky chain directed toward helix 12. J. Biol. Chem. 282: 30910-30919
  • Faucher, F., Cantin, L., Pereira de Jésus-Tran, K., Lemieux, M., Luu-The, V., Labrie, F., and Breton, R. (2007) Mouse 17α-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J. Mol. Biol. 369: 525-540.
  • Roy, J., Breton, R., Martel, C., Labrie, F., and Poirier, D. (2007) Chemical synthesis and biological activities of 16a-derivatives of 5α-androstane-3α,17β-diol as antiandrogens. Bioorg. Med. Chem. 15: 3003-3018.
  • Faucher, F., Pereira de Jésus-Tran, K., Cantin, L., Luu-The, V., Labrie, F., and Breton, R. (2006) Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. J. Mol. Biol. 364: 747-763.
  • Pereira de Jésus-Tran, K., Côté, P.-L., Cantin, L., Blanchet, J., Labrie, F., and Breton, R. (2006) Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Science 15: 987-999.
  • Trudel, É., Beaufils, S., Renault, A., Breton, R., and Salesse, C. (2006) Binding of RPE65 fragments to lipid monolayers and identification of its partners by GST pull-down assays. Biochemistry 45: 3337-3347
  • Bellemare, V., Faucher, F., Breton, R., and Luu-The, V. (2005) Characterization of 17α-hydroxysteroid dehydrogenase activity (17α-HSD) and its involvement in the biosynthesis of epitestosterone. BMC Biochem. 6: 12-22
  • Couture, J.-F., Pereira de Jésus-Tran, K., Roy, A.-M., Legrand, P., Cantin, L., Côté, P.-L., Luu-The, V., Labrie, F., and Breton, R. (2005) Comparison of crystal structure of human type 3 3α-hydroxysteroid dehydrogenase reveals an « induce-fit » mechanism and a conserved basic motif involved in the binding of androgen. Protein Science 14: 1485-1497
  • Couture, J.-F, Legrand, P., Cantin, L., Luu-The, V., Labrie, F., and Breton, R. (2004) Loop relaxation, a mechanism which explains the reduced specificity of rabbit 20α-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J. Mol Biol. 339: 89-102.
  • Dumont, M., Frank, D., Moisan, A.-M., Tranchant, M., Soucy, P., Breton, R., Labrie, F., Tavtigian, S. V., and Simard, J. (2004) Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. BBA – Gene Structure and Expression 1679: 230-247.
  • Couture, J.-F, Legrand, P., Cantin, L., Luu-The, V., Labrie, F., and Breton, R. (2003) Human 20α-Hydroxysteroid Dehydrogenase: Crystallographic and Site-directed Mutagenesis Studies Lead to the Identification of an Alternative Binding Site for C21-steroids. J. Mol. Biol. 331: 593-604.
  • Richard, M., Thibault, N., Veilleux, P., Breton, R., and Beaulieu, A. D. (2003) The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. Biochemical and Biophysical Research Communication 310: 767-773.
  • Couture, J.-F, Cantin, L., Legrand, P., Luu-The, V., Labrie, F., and Breton, R. (2002) Expression, crystallization and preliminary X-ray analysis of human and rabbit 20α-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates. Acta Crystallogr. D Biol. Crystallogr. 58: 135-139.
  • Raymond, K., Bergeret, E., Dagher, M. C., Breton, R., Griffin-Shea, R., Fauvarque, M. O. (2001) The Rac GTPase-activating Protein RotundRacGAP Interferes with Drac1 and Dcdc42 Signalling in Drosophila melanogaster. J. Biol. Chem. 276: 35909-35916.
  • Nahoum, V., Gangloff, A., Legrand, P., Zhu, D. W., Cantin, L., Zhorov, B., Luu-The, V., Labrie, F., Breton†, R., and Lin†, S. X. (2001) Structure of the human 3α-HSD type 3 in complex with testosterone and NADP at 1.25 Å resolution. J. Biol. Chem. 276: 42091-42098.
  • Zhu, D. W., Cantin, L., Nahoum, V., Rehse, P., Luu-The, V., Labrie, F., Breton, R, and Lin, S. X. (2001) Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3α-hydroxysteroid dehydrogenase at 1.8 A resolution. Acta Crystallogr. D Biol. Crystallogr. 57: 589-591.
  • Barbier, O., Girard, C., Breton, R., Bélanger, A., and Hum, D. W. (2000) N-Glycosylation and Residue 96 are Involved in the Functional Properties of UDP-Glucoronosyltransferase Enzymes. Biochemistry 39: 11540-11552.
  • Beaudoin, C., Lavallée, B., Tremblay, Y., Hum, D. W., Breton, R., de Launoit, Y, and Bélanger, A., (1998) Modulation of 17α-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis. DNA Cell Biol. 17: 707-715.
  • Mazza, C., Breton, R., Housset, D., and Fontecilla-Camps, J. C. (1998) Unusual Charge Stabilization of NADP+ in 17β-hydroxysteroid Dehydrogenase. J. Biol. Chem. 273: 8145-8152.
  • Labrie, F., Luu-The, V., Lin, S.-X., Labrie, C., Simard, J., Breton, R., and Bélanger, A. (1997) The key role of 17ß-HSDs in sex steroid Biology. Steroids 62: 148-158
  • Zhou, M., Breton, R., and Lin, S.-X. (1996) Rapid Purification of the Over-Expressed membrane 3ß-Hydroxysteroid Dehydrogenase in the Presence of Detergents. J. Crist. Growth 168: 142-149
  • Lin, S.-X., Zhu, D.-W., Azzi, A., Campbell, R. L., Breton, R., Labrie, F., Ghosh, D., Pletnev, V., Duax, W. L., and Pangborn, W. (1996) Studies on the 3 dimensional structure of estrogenic 17ß-hydroxysteriod dehydrogenase. J. Endocrinol. 150: 13-20
  • Breton, R., Housset, D., Mazza, C., and Fontecilla-Camps, J. C. (1996) The structure of a complex of human 17-ß hydroxysteroid with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure 4: 905-915
  • Breton, R., Yang, F., Jin, J.-Z., Li, B., Labrie, F., and Lin, S.-X. (1994) Human 17ß-Hydroxysteroid Dehydrogenase: Overproduction using a Baculovirus Expression System and Characterization. J. Steroid Biochem. Molec. Biol. 50: 275-282
  • Gagnon, Y., Breton, R., Putzer, H., Pelchat, M., Grunberg-Manago, M., and Lapointe, J. (1994) Clustering and Co-transcription of the Bacillus subtilis Genes Encoding the Aminoacyl-tRNA Synthetases Specific for Glutamate and for Cysteine and the First Enzyme for Cysteine Biosynthesis. J. Biol. Chem. 269: 7473-7482
  • Zhu, D.-W., Lee, X., Breton, R., Ghosh, D., Pangborn, W., Duax, W.L. and Lin, S.-X. (1993) Crystallization and preliminary X-Ray diffraction analysis of the complex of human 17ß-Hydroxysteroid Dehydrogenase with NADP+. J. Mol. Biol. 234: 242-244
  • Lin, S.-X., Yang, F., Jin, J.-Z., Breton, R. Zhu, D.-W., Luu-The, V., and Labrie, F. (1992) Subunit identity of the dimeric 17ß-Hydroxysteroid Dehydrogenase from human placenta. J. Biol. Chem. 267: 16182-16187
  • Brun, Y. V., Breton, R., and Lapointe, J. (1991) Large scale sequencing projects using rapidly prepared double-stranded plasmid DNA. DNA Sequence 1: 285-289.
  • Brun, Y. V., Breton, R., Lanouette, P., and Lapointe, J. (1990) Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. J. Mol. Biol. 214: 825-843.
  • Brun, Y. V., Sanfaçon, H., Breton, and R., Lapointe, J. (1990) Closely spaced and divergent promoters for an aminoacyl-tRNA synthetase gene and a tRNA operon in Escherichia coli. Transcriptional and post-transcriptional regulation of gltX, valU and alaW. J. Mol. Biol. 214: 845-864.
  • Breton, R., Watson, D., Yaguchi, M., and Lapointe, J. (1990) Glutamyl-tRNA synthetases of Bacillus subtilis 168T and of Bacillus stearothermophilus. Cloning and sequencing of the gltX genes and comparison with other aminoacyl-tRNA synthetases. J. Biol. Chem. 265: 18248-18255.
  • Breton, R., Sanfaçon, H., Papayannopoulos, I., Biemann, K., and Lapointe, J. (1986) Glutamyl-tRNA synthetase of Escherichia coli. Isolation and primary structure of the gltX gene and homology with other aminoacyl-tRNA synthetases. J. Biol. Chem. 261: 10610-10617.

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